Vitamin D3 could play a crucial role – medical practice

Periodontitis: Vitamin D3 as adjunctive therapy?

periodontitis is a disease that affects both the gums and the periodontium. If left untreated, it can result teeth will be released and subsequently fail. and therapy periodontitis depends on the severity of the disease. It could also help Vitamin D3as scientific studies show.

As explained in the article “scilog”, the journal of the Austrian Scientific Fund FWF (Fund for the Promotion of Scientific Research), periodontitis is an inflammatory disease of the periodontium. Treatment and regeneration is a major challenge for dentistry. Cell biologist Oleh Andrukhov examines dental stem cells in interaction with the immune system. His data show that vitamin D3, among others, plays a key role here.

Oral cavity colonized by various bacteria

The gateway to the body is an oral cavity colonized by a particularly large number of different bacteria. Most of them are beneficial for humans, the body’s own immune system is usually able to prevent the less helpful rest.

But take it specific bacteria prevails, a weakened immune system is no longer able to fight pathogens. This condition can lead to periodontitis, which can lead to chronic periodontitis and eventual loss of the tooth if left untreated.

The overall picture of this complicated The process of inflammation The basic interaction has now been enriched by a piece of the puzzle thanks to researchers from Austria.

Different immunomodulatory abilities

“We know that so-called dental mesenchymal stem cells (MSCs) play a vital role.”explains Oleh Andrukhov from the University Dental Clinic in Vienna. “Until now, we have considered them mainly as a useful tool for tissue regeneration. But they also have the ability to affect immune cells. They therefore have an immunomodulatory effect. “

Recent studies suggest that MSCs have different ones immunomodulatory abilities own. However, these differences have never been systematically examined. A team led by cell biologist Oleh Andrukhov has now taken on the task.

In addition, the researchers hypothesized that the interaction of dental MSCs with immune cells plays a crucial role in periodontitis. They also investigated the effect of vitamin D3 on this interaction. Reason: “It has long been assumed that a Mangel and vitamin D3 AND Risk factor for periodontitis. “

A perfectly balanced system found

The scientists isolated themselves for investigation blood cells from dental and generally physically healthy and mesenchymal subjects stem cells (progenitor cells) from extracted (ripped) teeth.

“In order to investigate the interaction between stem and immune cells and vitamin D3, we have developed our own model.”, Andrukhov explains. Together with his team, he found a perfectly balanced system. “There is a constant two-way interaction between immune cells and dental stem cells.”

This interaction is usually self-balancing, but ultimately depends on the locals conditions in the oral cavityespecially the presence of pro-inflammatory cytokines (carriers of immune cells).

On the one hand, the production of cytokines by immune cells activates dental MSCs, and on the other hand, dental MSCs suppress the activity of immune cells, leading to lower cytokine production. According to experts, this is a balance interaction they are necessary for the progression of periodontitis and for the regeneration of dental tissue.

Vitamin D3 in higher doses as adjunctive therapy

In addition, the data showed that this balanced interaction between immune cells and dental MSC is affected by vitamin D3 in various ways.

As explained in the article, vitamin D3 inhibits the activity of various immune cells and thus reduces the production of proinflammatory cytokines. At the same time, they are inhibited by vitamin D3 immunomodulatory activity from dental MSCs.

These properties of vitamin D3, in turn, are inhibited by bacterial factors as well cytokines regulated. Thus, vitamin D3 affects local conditions and at the same time its bioactivity is modulated by these conditions.

This suggests that vitamin D3 is consumed in higher doses than adjunctive therapy could be used in periodontitis and, conversely, the effectiveness of vitamin D3 could be improved by changing local conditions.

“However, optimal conditions have yet to be explored”, according to Andrukhov. In any case, the results open up a new perspective for future research projects.

Previous researchers’ results have been published in the Journal of Periodontal Research, the Journal of Clinical Periodontology, Cells and the World Journal of Stem Cells. (advertisement)

Author and resource information

This text conforms to the specifications of the medical literature, medical recommendations and current studies and has been reviewed by medical experts.

Sources:

  • scilog, Journal of the Austrian Science Fund FWF: New Approaches to the Treatment of Periodontitis, (accessed: June 22, 2022), scilog
  • Blufstein A., Behm C., Kubin B., Gahn J., Moritz A., Rausch-Fan X., Andrukhov O .: Influence of vitamin D3 on osteogenic differentiation of human periodontal fibrous stromal cells in inflammatory conditions; in: Journal of Periodontal Research, (published: 05.02.2021), Journal of Periodontal Research
  • Behm C., Blufstein A., Gahn J., Kubin B., Moritz A., Rausch-Fan X., Andrukhov O .: Pleiotropic effects of vitamin D3 on CD4 + T cells mediated by human periodontal fibrous cells and the inflammatory environment; in: Journal of Clinical Periodontology, (veröffentlicht: 11.03.2020), Journal of Clinical Periodontology
  • Behm C., Blufstein A., Gahn J., Nemec M., Moritz A., Rausch-Fan X., Andrukhov O .: Cytokines differently define the immunomodulation of mesenchymal stem cells from the periodontal ligament; in: Cells, (published: 14.05.2020), Cells
  • Andrukhov O., Behm C., Blufstein A., Rausch-Fan X .: Immunomodulatory properties of mesenchymal stem cells derived from dental tissue: implications for disease and tissue regeneration; in: World Journal of Stem Cells, (published: 26.09.2019), World Journal of Stem Cells

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It can’t replace a doctor’s visit.

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