The risk of the corona increases with recurrent infection

If you take a closer look at the authors’ data, you can see that people with reinfection double the risk of dying from Covid-19, as well as cardiovascular and pulmonary complications, compared to those who have only one infection. The risk of admission to the hospital even triples. True, the highest probability of these side effects is immediately after reinfection. However, the risk of most of these complications remains and tends to decline for up to six months. An increased risk for all of these vital functions was found, regardless of whether patients were vaccinated one or more times before the second infection. The study was previously published online as a preprint and has not yet been reviewed by experts.

This is a new quality of risk associated with the occurrence of the omicron variant. While reinfections before the omicron wave were relatively rare at <1 percent up to the delta wave, they now occur much more frequently. This is due to the high immune escape potential of omicron variants BA.2, BA.2.12.1, BA.4 and BA.5, which means that immune protection after infection is very effectively circumvented.

Finally, this study clearly demonstrates that reinfection is not trivial in terms of all-cause mortality, hospitalization, and adverse health consequences in the acute and post-acute phases. The authors conclude that reinfection prevention strategies are urgently needed to reduce the overall burden of deaths and diseases caused by SARS-CoV-2.

The authors use data from the US Department of Veterans Affairs’ national health databases for their analysis. They define three different cohorts:

  • people who were once infected (257,427 participants),
  • People who have recovered from Covid-19 at least twice (38,926 participants) and
  • People who have not yet been infected (control group, 5,396,855 participants).

Which: DOI 10.21203 / rs.3.rs-1749502 / v1

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