The intestinal flora affects the severity of heart disease – medical practice

How the intestinal microbiome affects the course of heart failure

Lack Diversity of microorganisms in the intestine According to the current overview of the course Heart failure (heart failure) adversely affect. sick with one intestinal flora out of balance must therefore more often to the hospital be accepted and have and increased risk of death due to heart disease.

researchers from Georgetown University Medical Center in Washington DC (USA) gathered evidence from more than 500 studies showing that a lower biodiversity in intestinal microorganisms WITH more severe heart failure is connected. The results of the review were recently presented in Heart Failure Reviews.

The intestine hides the entire ecosystem

Our Darmicrobiomeoften like “Darmflora“, Is a finely balanced ecosystem that consists mainly of many different species of bacteria. In addition, various viruses, fungi and protozoa settle in the gut.

Previous studies have shown that the intestinal flora central role in human health plays. The body needs metabolic products that produce intestinal bacteria to stay healthy.

The intestinal flora is even connected to the brain through the so-called gut-brain axis. A working group at Georgetown University Medical Center has now shown that it also affects the germ microbiome The course of cardiovascular diseases may affect.

The intestinal flora is not considered sufficient in medicine

“We rely on certain findings and test results to diagnose and treat heart failure, but we don’t know how poor heart function affects bowel function.”explains the author of the corresponding study Professor Dr. Kelley Anderson.

According to her, it has not yet been taken into account how ingested food and medicines change the intestinal flora and how the change in the intestinal flora affects the course of the disease.

Interaction between the intestinal flora and the cardiovascular system

“There is now an understanding of the relationship between the heart and the elements in the gut, because the heart and blood vessels clearly do not work in isolation.”emphasizes Professor Anderson.

The health of the cardiovascular system can affect the health of the intestinal flora and vice versa. Clear evidence for this is currently being developed in current studies.

The connection was proposed in 511 studies

In recent years, more advanced technologies have provided a better understanding of the complex relationship between gut microorganisms and human health.

The team gathered and evaluated 511 research articleswhich were published between 2014 and 2021. In all articles a Relationship between intestinal microbiome and heart health suggested. The researchers found out 30 studies of particular importance.

Effects of some metabolites of intestinal bacteria

An example of a compound is the metabolite called Trimethylamine N-oxide (TMAO) – a metabolite of certain intestinal bacteria that may affect cardiovascular health.

TMAO will increase though Consumption of whole dairy products, egg yolks and red meat if one produces unbalanced intestinal flora present, gift.

Diet affects the intestinal flora and heart health

Researchers emphasize that nutrition is an important part of overall cardiovascular health. Nutrition also affects the composition of the intestinal microbiome.

However, the subtleties of this interaction are not yet sufficiently understood. According to Dr. Anderson, they are currently conducting studies that examine how to use it Antibiotics, prebiotics and probiotics affect the microbiome in the gut.

Read the severity of heart disease from the intestinal flora

Overall, the working group sees great potential in influencing the intestinal flora for the treatment of heart diseases such as heart failure.

“We are currently developing a pioneering study to assess the microbiome in patients with heart failure.”, summarizes the author of the study. (vb)

Author and resource information

This text conforms to the specifications of the medical literature, medical recommendations and current studies and has been reviewed by medical experts.


Postgraduate editor (FH) Volker Blašek


  • Georgetown University Medical Center: Deficiency of microorganism diversity in the gut or increased metabolite involved in the severity of heart failure (veröffentlicht: 20.06.2022),
  • Kelley M. Anderson, Erin P. Ferranti, Emily Couvillon Alagha et al .: The relationship between the heart and the intestine: a systematic review of microbiome and trimethylamine-N-oxide (TMAO) assessment in heart failure; in: Heart Failure Reviews (2022),

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It can’t replace a doctor’s visit.

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