Influence of intestinal microflora on the severity of COVID-19
disease COVID-19 it attacks not only the tissue of the airways, but also the composition of the intestinal microbiota (intestinal flora), which affects the severity of the course of the disease. The consequences persist long after overcoming the viral infection.
In a new study involving experts from Campinas State University investigated the functional role of the intestinal microflora in the long-term consequences of COVID-19. The results were published on the English-language prepress server “Research Square”.
Effects of COVID-19 on intestinal health
After I got COVID-19, long-term consequences which have a significant impact on the lives of those affected. Here the question arose as to whether there could be a connection with Changes in the intestinal microbiota exists, the researchers explain.
Experts have now found in their research that the intestinal microflora after infection with COVID-19 (up to four months after the first positive test) shows a remarkable dominance of the so-called Enterobacteriaceae strains with a multi-resistant phenotype shows in comparison with healthy people from the control group.
Increased pneumonia caused by intestinal microflora
After the team transferred feces from participants to germ-free mice, animals fed samples from COVID-19 patients showed one more severe pneumonia and one more increased susceptibility to lung infectionscaused by a resistant strain of Klebsiella pneumoniae.
Cognitive performance decreased
These mice also showed one worse cognitive performance, which has been associated with increased TNF-α expression, decreased levels of something called neurotrophic factor BDNF and the postsynaptic protein density PSD-95 in the brain, experts said. In addition, it also happened Changes in various biochemical signaling pathways on.
These changes were observed in the absence of SARS-CoV-2, so according to the researchers, yes Changes in the intestinal microbiota are due. The study also clearly showed that the effects of SARS-CoV-2 infection on the intestinal microflora persist even after the affected patients have long since overcome acute viral infection.
Healthy bacteria prevent brain dysfunction
However, functional brain disorders found in a mouse model of coronavirus infection could be partially corrected Microbiota modulation treatment with probiotic bacterium Bifidobacterium longum 51A prevented, the team reports.
Overall, the results of the new research underline The importance of microbiots as a target of therapies Treatment of so-called post-COVID consequences, sums up the experts. (as)
Author and resource information
This text corresponds to the specifications of the medical literature, medical recommendations and current studies and has been reviewed by medical professionals.
- Viviani Mendes de Almeida, Daiane F. Engel, Mayra Fernando Ricci, Clênio Silva Cruz, Icaro Santos Lopes et al .: The intestinal microflora in patients with mild COVID-19 causes changes in mice that resemble the syndrome after COVID; in: Research Square (published June 22, 2022), Research Square
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.