Special molecule critical for health benefits from exercise – medical practice

Reduce obesity without exercise

Identifying the molecule produced by exercise in the blood could, in the future, make it possible to reduce food intake while fighting obesity. Also development and Medicines be allowed to teaches the benefits of sportwithout having to move.

In a new study involving experts from Stanford Medical School investigated which molecular and cellular mechanisms mediate the metabolic benefits of physical activity.

The results were published in the English-language journal “Nature”.

What is Lac Phe?

In their research, the researchers conducted a comprehensive Analysis of blood plasma compounds mice after intense training on a treadmill. One molecule that was most affected turned out to be a modified amino acid label Lac-Phe Yippee.

Lac-Phe is off Lactate (a by – product of strenuous exercise that is responsible for the burning sensation in the muscles) a phenylalanine (an amino acid that is one of the building blocks of protein), the team explains.

Physical activity helps with weight loss

Regular exercise has been shown to help you lose weight, regulate your appetite and improve your metabolic profile, especially in overweight and obese people.“Explains the author of the study Professor Dr. Yong Xu in a press release from Baylor College of Medicine.

Understanding the mechanism by which exercise triggers these benefits could help many people to improve their health, the doctor continues. “We wanted to understand how motion works at the molecular level so we can take advantage of some of its benefits“Adds the author of the study Dr. Jonathan Long he added.

Benefits of exercise when taking medication

According to Dr. One day long, for example in the elderly or sick who can no longer move adequately take drugs progress osteoporosis, heart disease or to slow down other diseases.

50 percent lower food intake thanks to Lac-Phe

The study showed that a high dose Lac-Phe in obese mice, the intake of the high – fat diet consumed by the animals over 12 hours increased by approximately 50 percent suppressed compared to control mice. According to the team, movement and energy consumption were not affected.

Lower body weight and improved glucose tolerance

It was administered to the animals for a period of ten days Filed Lac-Phe lowered cumulative food intake and body weight (due to the loss of body fat) and at the same time improved glucose tolerance, experts add.

In addition, the team also managed to create an enzyme called CNDP2 identify who is involved in the production of Lac-Phe. The research group found that mice lacking this enzyme did not lose as much weight in the exercise program as the control group with the same exercise regimen.

The results also seem to apply to humans and horses

One is with people and also with racehorses a sharp increase in Lac-Phe plasma levels after exercise, researchers report. This was shown, for example, by data from the human training cohort sprint training showed the largest increase in Lac-Phe plasma levels followed by resistance training and endurance training.

Lac-Phe as a system of nutrition regulation

This suggests that Lac-Phe is an ancient and conserved system that regulates nutrition and is associated with physical activity in many species of animals.“He explained.” Dr. Long.

Our next step is to find more details on how Lac-Phe mediates its effects in the body, including the brain. Our goal is to understand how to modulate this pathway for therapeutic interventions“Adds the author of the study Professor Dr. Xu he added.

Further research in this area may one day lead to medicine which mediates the health benefits of exercise and accompanying weight loss without the involvement of people who would actually need to exercise. (as)

Author and resource information

This text conforms to the specifications of the medical literature, medical recommendations and current studies and has been reviewed by medical experts.


  • Veronica L. Li, Yang He, Kevin Contrepois, Hailan Liu, Joon T. Kim et al .: Exercise-inducible metabolite that suppresses feeding and obesity; in: Nature (veröffentlicht 15.06.2022), Nature
  • Baylor College of Medicine: Benefits of Exercise in Pills? Science is closer to this goal (veröffentlicht 15.06.2022), Baylor College of Medicine

Important note:
This article contains general advice only and should not be used for self-diagnosis or treatment. It can’t replace a doctor’s visit.

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