Neutralize the HIV virus with antibodies
An Israeli research team has developed a new method to help HIV infection and AIDS can be cured with a single treatment. The team was able to modulate immune cells in such a way that they could neutralize HI viruses.
researchers from Tel Aviv University in Israel in a recent study showed that a new method can be used to activate the immune system in the fight against HI viruses. The results, which were recently presented in the renowned magazine “Nature”, could lead to curative treatment of HIV infection lead.
AIDS therapeutic therapy in perspective
It currently exists no permanent cure for HIV infection and AIDS. The available therapies aim keep the virus under control. Nevertheless, the lives of many people affected have improved significantly over the last two decades thanks to new treatments.
That’s how it happened once the deadly disease of AIDS do a lifelong chronic disease degraded. Israeli scientists now want to go one step further and get sick finally beat.
Team around Dr. Adi Barzel a doctoral student Alessio Nehmad has now presented the basis for therapeutic therapy against HIV and AIDS with the current results of the study.
“Based on this study, we can expect to be able to produce a cure for AIDS, other infectious diseases and certain types of cancers caused by the virus in the next few years, such as cervical cancer, head and neck cancer and more. flight.”, confirms Dr. barcel.
The method causes the immune system to produce antibodies to HIV
The team used the latest methods of gene modification technology white blood cells type B do it Stimulate the immune system to produce HIV-neutralizing antibodies.
“We have developed an innovative treatment that can defeat the virus with a single injection and has the potential to significantly improve patients.”, emphasizes Dr. barcel.
What HI viruses do to the body
The ones that belong to the white blood cells B cells they are in it in the body antibody production against viruses, bacteria and other pathogens. They form in the bone marrow and travel to various parts of the body through the blood and lymphatic systems.
That HI-Virus destroys the white blood cells in the body that are responsible Central importance of the immune system they are. In this way, viruses weaken the immune system against any infection.
Arms race in the immune system
Participating scientists have now succeeded in modifying type B white blood cells in such a way that they have Induce the production of antibodies that neutralize HIV. Altered blood cells could be given as a single injection.
According to the study director, in the study, the B cells were engineered to divide upon encounter with the HI virus. In this way, viruses can be combated more effectively.
However, the insidious thing about HI viruses is that they change and antibodies can no longer be recognized. and altered B cells recognize this change however a also changeand adapted antibodies take out.
“So we created the first drug that did it.” develop in the body and Defeat viruses in arms races to be able to “, educates Dr. barzel ven. The method has already been used in mice successfully tested.
Method based on CRISPR technology
Genetic manipulation of B cells was performed using the so-called CRISPR technology. The technique was derived from bacteria that use a kind of “gene scissors” to find viral sequences and cut them to knock them out. (vb)
Author and resource information
This text corresponds to the specifications of the medical literature, medical recommendations and current studies and has been reviewed by medical professionals.
Postgraduate editor (FH) Volker Blašek
- Tel Aviv University: Breakthrough technology could lead to a single treatment for HIV (published: 14.06.2022), english.tau.ac.il
- Alessio D. Nahmad, Cicera R. Lazzarotto, Natalie Zelikson et al .: In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice; in: Nature (2022), nature.com
This article contains general advice only and should not be used for self-diagnosis or treatment. It cannot replace a visit to the doctor.