ASA can slow the spread of colon cancer

Updated: 15.06.2022 – 15:21

It slows down mutations
ASA can slow the spread of colon cancer

The over-the-counter pain medication ASA is said to help stop colon cancer.

Photo: Getty Images / Ignatiev

The over-the-counter pain medication ASA is said to help stop colon cancer.

According to a recent study, acetylsalicylic acid (ASA), which is used to treat pain and mild fever, can also slow down the spread of colon cancer.

Colorectal cancer is one of the most dangerous forms of cancer, because the symptoms often appear only when the disease is already in an advanced stage. That is why regular inspections are particularly important. It now seems to be a known and widespread pain medication as a treatment option. According to a recent study, the painkiller ASA (acetylsalicylic acid) is said to slow the progression of the disease.

ASA can slow the growth of colon cancer

ASA is used mainly for mild pain, such as headaches, but also for fever. The active ingredient also has anti-inflammatory properties. The results of an American study now show that the use of ASA prevents the proliferation of colon cancer cells and also makes it more difficult for them to survive. ASA slows down the division of tumor cells and at the same time increases cell death, according to

“Cancer occurs because the cells go from a healthy state to a disease state where they are constantly dividing. This happens when the cells acquire a number of mutations and these mutations are selected. We have found that aspirin (trade name ASA) affects and slows down this process. formation slows down, ”explains co-author Dominik Wodarz, a professor of public health and disease prevention at the University of California.

Mathematical model for broad prediction

Using a mathematical model, the researchers were able to make a broad prediction at the population level if the cell kinetics (cell movement and reaction processes) were changed by ASA. “We thought that the delayed development of cancer due to ASA (aspirin) must be the result of the delayed development of cells towards malignant change. We were surprised that this mechanism explains quite well the level of protection observed in the human population. protective effect observed in epidemiological studies in the human population, “explains the main author and mathematician Natalia Komarová.

And Dominik Wodarz adds: “This work is an example of how mathematical approaches can be very useful for understanding complex phenomena in cancer biology. Such knowledge would not be possible only through experiments. It requires the cooperation of empirical biological work and mathematics.”



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