Approach to pancreatic regeneration
in Diabetes The body often can’t do enough Insulin produce to blood sugar levels lower enough. People with disabilities are therefore often dependent on insulin injections. The new therapeutic approach aims to stimulate insulin-producing cells pancreas to regenerate so that sufficient endogenous insulin can be produced again.
researchers from Karolinska Institutet in Sweden, they deciphered a mechanism that could stimulate the pancreas to make new insulin-producing cells. The results of the research were recently presented in the renowned journal “Nature Chemical Biology”.
Insulin balance plays a central role in diabetes
Insulin is a hormone needed to absorb sugar (glucose) from the blood. Elevated blood sugar levels are characteristic of type 1 and type 2 diabetes. High blood sugar is on one Lack of endogenous insulin due to or inability to use the released insulin.
Diabetes is currently not treatable
Diabetes can be brought under control with a healthy lifestyle with a modified diet, insulin injections or blood sugar lowering drugs, but according to the current state of knowledge, metabolic diseases cannot be cured.
“Therefore, we are investigating the possible regeneration of insulin-producing β-cells in the pancreas”explains the first author of the study Christos Karampelias.
A new approach to diabetes treatment
The Swedish research group has now presented its latest study results therapeutic treatment of diabetes could be within reach. The team identified a mechanism for Restoration of β-cells in the pancreas.
“Our results point to a new potential target for diabetes treatment”confirms the lead researcher Dr. Olov Andersson. The goal is to regulate blood sugar levels by stimulating the pancreas to produce more β-cells and then more insulin.
The molecule stimulates β-cell production
In a previous study, a team from the Karolinska Institutet had a molecule called CID661578 he found out, that Regeneration of insulin-producing β-cells can stimulate. In current work, scientists have been able to decode the basic mechanisms of this process.
Insulin production could be increased
As the working group found out, he is binding MNK2 protein names to the discovered molecule. Binding stimulates certain processes that stimulate the formation of new β-cells in the pancreas.
In zebrafish, pigs and human organoids The newly discovered molecule can already increase insulin production.
Not tested on humans yet
“We will now examine the effect of this and similar molecules in human tissue and analyze the target protein molecule, MNK2, in tissue from healthy diabetic donors.”, explains Dr. Andersson next steps. (vb)
Author and resource information
This text complies with the requirements of the medical literature, medical guidelines and current studies and has been reviewed by medical experts.
Postgraduate editor (FH) Volker Blašek
- Karolinska Institutet: The study describes a new way of generating insulin-producing cells (published: 13.06.2022), news.ki.se
- Karampelias, C., Watt, K., Mattsson, CL et al. MNK2 deficiency potentiates β-cell regeneration through translational regulation. Nat Chem Biol (2022). https://doi.org/10.1038/s41589-022-01047-x, nature.com
This article contains general advice only and should not be used for self-diagnosis or treatment. It can’t replace a doctor’s visit.